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Rumex hastatus derived silver nanoparticles development and their potential applications as hepatic-protection agent along with antimicrobial activity
Journal of King Saud University-Science ( IF 3.8 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.jksus.2021.101587
Hina Gul 1 , Falak Sher Khan 2 , Umara Afzal 3 , Salma Batool 4 , Salina Saddick 5 , Muhammad Awais 6 , Samra Irum 7 , M.Y. Malik 8 , M. Ijaz Khan 9 , Alaa Alhazmi 10, 11 , Sami Ullah Khan 12
Affiliation  

Current study aimed to develop eco-friendly and cost-effective approaches for silver nanoparticle (AgNPs) synthesis using leaf extract of Rumex hastatus and characterization using various analytical techniques. Besides, the crystallinity of Ag+, reduction/stability, functional groups and structural morphology were determined through X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR spectroscopy) and scanning electron microscopy (SEM) respectively. The biosynthesized RH-AgNPs were investigated for hepatoprotective and cytotoxic effect, antioxidative activities and antimicrobial potential. Results revealed that RH-AgNPs were effective against hepatotoxin (carbon tetrachloride) at all tested concentrations by exhibiting very valuable results; showed high antioxidant potential and cytotoxic effect against HepG2 cancer cell lines. RH-AgNPs showed very promising antibacterial results as well. Overall, these results highlighted the potential of RH-AgNPs to be used for the treatment of various diseases.



中文翻译:

Rumex hastatus 衍生的银纳米粒子的开发及其作为肝脏保护剂和抗菌活性的潜在应用

目前的研究旨在开发使用Rumex hastatus 的叶提取物合成银纳米颗粒 (AgNPs) 的环保且具有成本效益的方法,并使用各种分析技术进行表征。此外,Ag +的结晶度、还原/稳定性、官能团和结构形态分别通过 X 射线衍射 (XRD)、傅里叶变换红外光谱 (FT-IR 光谱) 和扫描电子显微镜 (SEM) 确定。研究了生物合成的 RH-AgNPs 的保肝和细胞毒作用、抗氧化活性和抗菌潜力。结果表明,RH-AgNPs 在所有测试浓度下均能有效对抗肝毒素(四氯化碳),表现出非常有价值的结果;对 HepG2 癌细胞系显示出高抗氧化潜力和细胞毒性作用。RH-AgNPs 也显示出非常有希望的抗菌结果。总体而言,这些结果突出了 RH-AgNPs 用于治疗各种疾病的潜力。

更新日期:2021-09-12
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