Mixed-matrix membranes with metal-organic frameworks (MOFs)-based dual-imprinted structure (MMM-MDIs) were prepared by choosing tetracycline (TC) as the template molecule. Polydopamine (PDA)-based TC-imprinted UiO-66 particles (PDA-TC-UiO-66) were constructed by developing a self-polymerization imprinting technique of dopamine, in which the dopamine molecule could be regarded as functional monomer and cross-linking agent in the same time. After the phase conversion membrane production, the sol-gel-based TC-imprinted structure could be then synthesized on the membrane surface. Importantly, due to the preparation of the dual-TC-imprinted structure in MMM-MDIs, high adsorption capacity (48.62 mg/g) and fast adsorption equilibrium rate (within 60 min) had been successfully achieved. Meanwhile, excellent permselectivity rates (β) of MMM-MDIs toward TC were also obtained as 6.33, 5.93 and 6.73, which demonstrated the successful synthesis of high-affinity and high-density TC-imprinted sites. Overall, based the practical selective separation and scalability analysis, we believed that the as-prepared MMM-MDIs with high-intensitive recognizability and permeability of template molecule would provide a possibility for breaking the permeability-selectivity trade-off of molecularly imprinted membrane materials.

通过选择四环素（TC）作为模板分子，制备了具有基于金属有机骨架（MOF）的双印迹结构（MMM-MDI）的混合基质膜。通过开发多巴胺的自聚合印迹技术构建了基于聚多巴胺（PDA）的TC印迹UiO-66颗粒（PDA-TC-UiO-66），其中多巴胺分子可以作为功能单体和交联同时代理。在相转换膜生产后，可以在膜表面合成溶胶凝胶基 TC 印迹结构。重要的是，由于在 MMM-MDI 中制备了双 TC 印迹结构，成功实现了高吸附容量（48.62 mg/g）和快速吸附平衡速率（60 分钟内）。同时，优异的渗透选择率（MMM-MDI 对 TC 的β ) 也为 6.33、5.93 和 6.73，这证明了高亲和力和高密度 TC 印迹位点的成功合成。总体而言，基于实际的选择性分离和可扩展性分析，我们认为所制备的具有模板分子高强度识别性和渗透性的 MMM-MDI 将为打破分子印迹膜材料的渗透性-选择性权衡提供可能。