Acute pancreatitis (AP) is a common acute abdominal disease with a mortality rate of about 30%. Acute lung injury (ALI) is a common systemic complication of acute pancreatitis, with progressive hypoxemia and respiratory distress as the main manifestations, which can develop into acute respiratory distress syndrome or even multiple organ dysfunction syndrome (MODS) in severe cases, endangering human health. In the model of AP, pathophysiological process of the lung can be summarized as oxidative stress injury, inflammatory factor infiltration, and alveolar cell apoptosis. However, the intrinsic mechanisms underlying AP and how it leads to ALI are not fully understood. In this paper, we summarize recent articles related to AP leading to ALI, including the signal transduction pathways and biomarkers of AP-ALI. There are factors or pathway aggravating ALI, the JAK2-STAT3 signaling pathway, NLRP3/NF-κB pathway, mitogen-activated protein kinase, PKC pathway, neutrophil protease (NP)-LAMC2-neutrophil pathway, and the P2X7 pathway, and there are important transcription factors in the NRF2 signal transduction pathway which could give researchers better understanding of the underlying mechanisms controlling AP and ALI and lay the foundation for finally curing ALI induced by AP.

中文翻译：

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急性胰腺炎致急性肺损伤的信号通路和标志物

急性胰腺炎（AP）是一种常见的急性腹部疾病，死亡率约为30%。急性肺损伤（ALI）是急性胰腺炎常见的全身并发症，以进行性低氧血症和呼吸窘迫为主要表现，严重者可发展为急性呼吸窘迫综合征甚至多器官功能障碍综合征（MODS），危害人类健康. 在AP模型中，肺的病理生理过程可概括为氧化应激损伤、炎症因子浸润和肺泡细胞凋亡。然而，AP 的内在机制以及它如何导致 ALI 尚不完全清楚。在本文中，我们总结了最近与导致 ALI 的 AP 相关的文章，包括 AP-ALI 的信号转导途径和生物标志物。κ B 通路、丝裂原活化蛋白激酶、PKC 通路、中性粒细胞蛋白酶 (NP)-LAMC2-中性粒细胞通路和 P2X7 通路，NRF2 信号转导通路中存在重要的转录因子，可以让研究人员更好地了解潜在的控制 AP 和 ALI 的机制，为最终治愈 AP 诱发的 ALI 奠定了基础。