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Synthesis and biological evaluation of antimalarial and antileukemic activity of new C-10 modified artemisinin derivatives
Tetrahedron ( IF 2.1 ) Pub Date : 2021-08-28 , DOI: 10.1016/j.tet.2021.132410
Farnoush Mousavizadeh 1 , Dimanthi Pliatsika 1 , Toni Smeilus 1 , Daniel Meyer 1 , Marcel Kaiser 2, 3 , Thomas Efferth 4 , Athanassios Giannis 1
Affiliation  

Several non-acetal artemisinin derivatives were synthesized and their antimalarial activity against chloroquine-resistant parasites as well as their antileukemic activity were investigated. The azide 10 was proved to have slightly better activity than the current antimalarial drugs such as artesunate and chloroquine. In addition, the azide 10 and the aldehyde 7 were found to be effective in decreasing cell proliferation in leukemia cells.



中文翻译:

新型 C-10 修饰青蒿素衍生物抗疟和抗白血病活性的合成和生物学评价

合成了几种非缩醛青蒿素衍生物,并研究了它们对氯喹抗性寄生虫的抗疟活性及其抗白血病活性。事实证明,叠氮化物10 的活性略好于目前的抗疟药青蒿琥酯和氯喹。此外,发现叠氮化物10和醛7可有效降低白血病细胞的细胞增殖。

更新日期:2021-09-24
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