The pathoanatomical correlate of temporal lobe epilepsy is hippocampal sclerosis, characterized by selective neuronal death of mossy cells in the hilus and of pyramidal cells in cornu ammonis 1. Although granule cells survive, they lose mossy cells as a target and redirect their axons (mossy fibers) backward into the molecular cell layer. It has been assumed that this process results in excitatory circuits. We therefore examined whether sprouted mossy fibers form synaptic connection not only with excitatory granule cells but also with inhibitory interneurons, such as basket cells.

中文翻译：

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颞叶癫痫中异常的海马苔藓纤维靶向兴奋性和抑制性神经元

颞叶癫痫的病理解剖学相关因素是海马硬化，其特征是门中苔藓细胞和角锥体细胞的选择性神经元死亡 1。虽然颗粒细胞存活，但它们会失去苔藓细胞作为靶标并重定向其轴突（苔藓纤维) 向后进入分子细胞层。假设这个过程会导致兴奋性电路。因此，我们检查了发芽的苔藓纤维是否不仅与兴奋性颗粒细胞形成突触连接，还与抑制性中间神经元（如篮状细胞）形成突触连接。