Bacterial infection and blockage are severe problems for polyurethane (PU) catheters and there is an urgent demand for surface-functionalized polyurethane. Herein, a cationic alternating copolymer comprising allyl-substituted ornithine and glycine (allyl-substituted poly(Orn-alter-Gly)) with abundant carbon–carbon double bond functional groups (C═C) is designed. Polyurethane is prepared with a large quantity of C═C groups (PU-D), and different amounts of allyl-substituted poly(Orn-alter-Gly) are grafted onto the PU-D surface (PU-D-2%AMPs and PU-D-20%AMPs) via the C═C functional groups. The chemical structures of the allyl-substituted poly(Orn-alter-Gly) and polyurethane samples (PU, PU-D, PU-D-2%AMPs, and PU-D-20%AMPs) are characterized and the results reveal that allyl-substituted poly(Orn-alter-Gly) is decorated on the polyurethane. PU-D-20%AMPs shows excellent antibacterial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus because of the high surface potential caused by cationic allyl-substituted poly(Orn-alter-Gly), and it also exhibits excellent long-term antibacterial activity and antibiofilm properties. PU-D-20%AMPs also has excellent antifouling properties because the cationic copolymer is fixed at multiple reactive sites, thus avoiding the formation of movable long chain brush. A strong surface hydration barrier is also formed to prevent adsorption of proteins and ions, and in vivo experiments reveal excellent biocompatibility. This flexible strategy to prepare dual-functional polyurethane surfaces with antibacterial and antifouling properties has large potential in biomedical implants.

中文翻译：

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阳离子交替多肽固定在聚氨酯上的多个部位，具有出色的抗菌和防污性能

细菌感染和堵塞是聚氨酯（PU）导管的严重问题，迫切需要表面功能化聚氨酯。在此，设计了一种包含烯丙基取代的鸟氨酸和甘氨酸的阳离子交替共聚物（烯丙基取代的聚（Orn-alter-Gly）），并具有丰富的碳碳双键官能团（C=C）。聚氨酯是用大量的 C=C 基团（PU-D）制备的，不同数量的烯丙基取代的聚（Orn-alter-Gly）接枝到 PU-D 表面（PU-D-2%AMPs 和PU-D-20%AMPs) 通过 C=C 官能团。表征了烯丙基取代的聚 (Orn-alter-Gly) 和聚氨酯样品（PU、PU-D、PU-D-2%AMPs 和 PU-D-20%AMPs）的化学结构，结果表明烯丙基取代的聚（Orn-alter-Gly）装饰在聚氨酯上。由于阳离子烯丙基取代的聚（Orn-alter-Gly）引起的高表面电位，大肠杆菌、粪肠球菌和金黄色葡萄球菌也表现出优异的长期抗菌活性和抗生物膜特性。PU-D-20%AMPs还具有优异的防污性能，因为阳离子共聚物固定在多个反应位点，从而避免形成可移动的长链刷。还形成了强大的表面水化屏障，以防止蛋白质和离子的吸附，体内实验显示出优异的生物相容性。这种制备具有抗菌和防污性能的双功能聚氨酯表面的灵活策略在生物医学植入物中具有巨大潜力。