Capturing, storing, and sharing biological DNA parts data are integral parts of synthetic biology research. Here, we detail updates to the ICE biological parts registry software platform that enable these processes, describe our implementation of the Web of Registries concept using ICE, and establish Bioparts, a search portal for biological parts available in the public domain. The Web of Registries enables standalone ICE installations to securely connect and form a distributed parts database. This distributed database allows users from one registry to query and access plasmid, strain, (DNA) part, plant seed, and protein entry types in other connected registries. Users can also transfer entries from one ICE registry to another or make them publicly accessible. Bioparts, the new search portal, combines the ease and convenience of modern web search engines with the capabilities of bioinformatics search tools such as BLAST. This portal, available at bioparts.org, allows anyone to search for publicly accessible biological part information (e.g., NCBI, iGEM, SynBioHub, Addgene), including parts publicly accessible through ICE Registries. Additionally, the portal offers a REST API that enables third-party applications and tools to access the portal’s functionality programmatically.

中文翻译：

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BioParts——一个生物部件搜索门户和 ICE 部件注册软件平台的更新

捕获、存储和共享生物 DNA 部分数据是合成生物学研究的组成部分。在这里，我们详细介绍了支持这些流程的 ICE 生物部件注册软件平台的更新，描述了我们使用 ICE 实施 Web of Registries 概念的方法，并建立了 Bioparts，这是一个公共领域中可用的生物部件搜索门户。Web of Registries 使独立的 ICE 安装能够安全地连接并形成分布式零件数据库。这个分布式数据库允许来自一个注册表的用户查询和访问其他连接注册表中的质粒、菌株、（DNA）部分、植物种子和蛋白质条目类型。用户还可以将条目从一个 ICE 注册中心转移到另一个注册中心或公开访问。Bioparts，新的搜索门户，结合了现代网络搜索引擎的易用性和生物信息学搜索工具（如 BLAST）的功能。该门户网站位于 bioparts.org，任何人都可以搜索可公开访问的生物部件信息（例如，NCBI、iGEM、SynBioHub、Addgene），包括可通过 ICE Registries 公开访问的部件。此外，门户提供 REST API，使第三方应用程序和工具能够以编程方式访问门户的功能。