Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase bla NDM-1, the extended-spectrum β-lactamase bla PER-1, and the rare 16S methyltransferase rmtB2.

中文翻译：

---

泛耐药性普罗维登西亚雷特吉里 (Providencia rettgeri) 导致 COVID-19 致命病例

在包括广谱抗生素暴露在内的长期住院治疗后，从一名因 COVID-19 导致的缺氧性呼吸衰竭而接受体外膜氧合治疗的患者的血液中培养出一种普罗维登西亚雷特盖氏菌菌株。该菌株对所有测试的抗菌剂都具有抗性，包括新型铁载体头孢菌素头孢菌素。全基因组测序检测到 10 个抗菌素耐药基因，包括金属-β-内酰胺酶bla NDM-1、超广谱 β-内酰胺酶bla PER-1和罕见的 16S 甲基转移酶rmtB2。