The FGFR signaling pathway is activated in multiple tumor types through gene amplifications, single base substitutions, or gene fusions. Novel FGFR gene fusions may represent candidate targets for the development of tyrosine kinase inhibitors.

中文翻译：

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FGFR2-TSC22D1，一种在结直肠癌患者中鉴定的新型 FGFR2 融合基因：病例报告。

FGFR 信号通路通过基因扩增、单碱基替换或基因融合在多种肿瘤类型中被激活。新型FGFR基因融合可能代表开发酪氨酸激酶抑制剂的候选目标。