Abstract

Background:

Fentanyl is a synthetic opioid with analgesic potency 75–100 times higher than that of morphine, and its analgesic effect is used for pain treatment, mostly in cancer patients. Using fentanyl patches may reduce misuse potential due to the transdermal route of administration, long-acting action, sustained release delivery property, and maintenance of steady-state serum concentration of the drug. Although there have been reports of transdermal fentanyl patches (TFPs) misuse via transmucosal, trans-nasal, intravenous, and oral routes of administration, fentanyl use disorder via the transdermal route is very rare.

Case:

In this case report, we present a patient with a history of substance use disorder who developed fentanyl use disorder via transdermal route after using unprescribed TFP in order to quit opium gum. The CARE guidance was followed in the preparation of this case report.

Conclusion:

The risk of use disorder may be higher, especially in individuals with a history of substance use disorders. This risk should be taken into account when clinicians prescribe this medication.

中文翻译：

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以非处方使用透皮贴剂为特征的芬太尼使用障碍：病例报告

摘要

背景：

芬太尼是一种合成的阿片类药物，镇痛效力比吗啡高 75-100 倍，其镇痛作用主要用于癌症患者的疼痛治疗。由于透皮给药途径、长效作用、缓释递送特性和维持药物稳态血清浓度，使用芬太尼贴剂可降低误用可能性。尽管有报道称经皮芬太尼贴剂 (TFP) 通过经粘膜、经鼻、静脉内和口服途径滥用，但经皮途径的芬太尼使用障碍非常罕见。

案子：

在本病例报告中，我们介绍了一名有物质使用障碍病史的患者，该患者在使用非处方 TFP 以戒掉鸦片胶后通过透皮途径发展为芬太尼使用障碍。本病例报告的编写遵循了 CARE 指南。

结论：

使用障碍的风险可能更高，尤其是在有物质使用障碍病史的个体中。当临床医生开出这种药物时，应考虑到这种风险。