Neurological Sciences ( IF 3.3 ) Pub Date : 2021-08-27 , DOI: 10.1007/s10072-021-05574-8 May Fouad Nassar 1 , Yasmin Gamal Abdou El-Gendy 1 , Mohamed Tarif Hamza 2 , Marwa Nasser Mohamed 3 , Nesrine Radwan 4
Background and aim of the work
Ketogenic diet (KD) is one of the treatments in drug-resistant epilepsy (DRE). The current study aimed at assessing the effect of KD-induced ketosis on different immunological cells since ketosis is reported to affect neutrophil function.
Methodology
We recruited 21 pediatric patients diagnosed with DRE assigned to start KD. Anthropometric measurements, complete blood picture with differential count, phagocytic function, lymphocyte subsets, and IgG estimation were estimated initially and after 6 months of KD.
Results
There were no differences between the initial total leucocytic, neutrophil, and lymphocytic counts as well as the lymphocyte subsets, and the values after 6 months of KD. IgG values showed significant increase yet the values were still within the reference ranges. For the innate immune system, the phagocytic index was assessed and it showed a marked statistical reduction in patients after KD.
Conclusion
KD has no effect on neutrophil and lymphocytic counts as well as the number of adaptive and immune cells; nevertheless, it causes a reduction in phagocytic index in DRE. Accordingly, further detailed study for the full immunological profile and function is needed to ensure the safety of this therapeutic line and correlate it with the clinical history.
中文翻译:
生酮饮食治疗耐药性癫痫对免疫细胞的影响
工作背景和目的
生酮饮食(KD)是耐药性癫痫(DRE)的治疗方法之一。目前的研究旨在评估 KD 诱导的酮症对不同免疫细胞的影响,因为据报道酮症会影响中性粒细胞功能。
方法
我们招募了 21 名诊断为 DRE 的儿科患者,他们被分配开始 KD。最初和 KD 6 个月后估计人体测量值、具有差异计数的全血图、吞噬功能、淋巴细胞亚群和 IgG 估计值。
结果
初始总白细胞、中性粒细胞和淋巴细胞计数以及淋巴细胞亚群与 KD 6 个月后的值之间没有差异。IgG值显示出显着增加,但值仍在参考范围内。对于先天免疫系统,评估了吞噬指数,结果显示 KD 患者在统计学上显着降低。
结论
KD 对中性粒细胞和淋巴细胞计数以及适应性和免疫细胞的数量没有影响;然而,它会导致 DRE 中的吞噬指数降低。因此,需要对完整的免疫学特征和功能进行进一步的详细研究,以确保该治疗线的安全性并将其与临床病史相关联。