Abstract

The review presents data on the expression of ghrelin receptor GHS-R1a in the brain in model animals (Danio rerio, rodents, primates), and in the human brain. Studies show widespread localization of GHS-R1a in the brain, which indicates the involvement of the receptor in many physiological processes. Using various models, information has been obtained regarding the participation of the receptor in the regulation of the pro- and anti-inflammatory response, apoptosis and proliferation. It is known that the ghrelin receptor plays an important role in eating behavior and is also involved in the pathogenetic mechanisms of obesity, drug addiction, and alcoholism. With this in mind, research is underway with the use of various therapeutic agents (receptor agonists and antagonists) that can be used for the pharmacological correction of these pathological conditions. This review also presents hypothetical mechanisms of intracellular signaling, in which GHS-R1a may participate; however, a complete understanding of these mechanisms has not yet been reached. The ghrelin intracellular pathways seem to be specific to brain region and, probably, also depend on the metabolic or stress status of the organism.

中文翻译：

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Ghrelin 受体 GHS-R1a 在大脑中的表达（迷你评论）

摘要

该评论提供了有关模型动物大脑中生长素释放肽受体 GHS-R1a 表达的数据 ( Danio rerio、啮齿动物、灵长类动物）和人脑。研究表明 GHS-R1a 在大脑中广泛定位，这表明受体参与了许多生理过程。使用各种模型，已获得有关受体参与调节促炎和抗炎反应、细胞凋亡和增殖的信息。众所周知，ghrelin 受体在饮食行为中起着重要作用，也参与肥胖、毒瘾和酗酒的发病机制。考虑到这一点，正在使用各种治疗剂（受体激动剂和拮抗剂）进行研究，这些药物可用于对这些病理状况进行药理学矫正。本综述还提出了细胞内信号传导的假设机制，GHS-R1a 可以参与其中；然而，尚未完全了解这些机制。ghrelin 细胞内通路似乎特定于大脑区域，并且可能还取决于生物体的代谢或压力状态。