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In Vitro Effects of Different Resveratrol Concentrations on the Structural State of Mitochondrial Membranes Isolated from Pea Leaves
Biophysics Pub Date : 2021-08-27 , DOI: 10.1134/s0006350921030052
N. Yu. Gerasimov 1 , O. V. Nevrova 1 , I. V. Zhigacheva 1 , A. N. Goloshchapov 1 , I. P. Generozova 2
Affiliation  

In this study, the effects of different concentrations of antioxidant resveratrol on microviscosity of mitochondrial membranes isolated from pea leaves were investigated. It was shown that resveratrol in physiological (5 × 10–6 M) and ultralow (5 × 10–14 M) doses changed the microviscosity and altered the structure of the membrane lipid bilayer. This antioxidant is thought to affect the activity of membrane proteins due to altered structures of lipid molecules that surround them and, in turn, influence mitochondrial activity and function. No change was found in the range between physiological and ultralow doses, which is a “dead” zone. Moreover, resveratrol in physiological concentrations was found to shift thermally induced structural transition to the lower temperature region; therefore, it can interfere with the normal regulation of natural processes



中文翻译:

不同浓度白藜芦醇对豌豆叶线粒体膜结构状态的体外影响

在这项研究中,研究了不同浓度的抗氧化剂白藜芦醇对豌豆叶中分离的线粒体膜微粘度的影响。结果表明,白藜芦醇在生理 (5 × 10 –6 M) 和超低 (5 × 10 –14M) 剂量改变了微粘度并改变了膜脂双层的结构。这种抗氧化剂被认为会影响膜蛋白的活性,因为它们会改变周围的脂质分子结构,进而影响线粒体的活性和功能。在生理剂量和超低剂量之间的范围内没有发现变化,这是一个“死”区。此外,发现生理浓度的白藜芦醇将热诱导的结构转变转移到较低温度区域;因此,它会干扰自然过程的正常调节

更新日期:2021-08-27
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