HMGB1 is one of the key proteins of the cell. HMGB1 performs its main functions predominantly in the cell nucleus, as an essential component of DNA–protein and multiprotein complexes. It plays an important role in various cellular processes, such as transcription, replication, and DNA repair. However, it has also been found outside the nucleus: in the cytoplasmic and extracellular space. Despite numerous publications on the structure and functioning of HMGB1, the molecular mechanisms that underlie the vast variety of functions performed by this protein still remain unclear. In this paper, we report recent data on the organization of the protein structure and its effects on HMGB1 interactions with DNA and other proteins.

HMGB1 是细胞的关键蛋白质之一。HMGB1 主要在细胞核中执行其主要功能，作为 DNA-蛋白质和多蛋白质复合物的重要组成部分。它在各种细胞过程中发挥着重要作用，例如转录、复制和 DNA 修复。然而，它也被发现在细胞核外：在细胞质和细胞外空间。尽管有大量关于 HMGB1 的结构和功能的出版物，但该蛋白质所执行的各种功能背后的分子机制仍不清楚。在本文中，我们报告了有关蛋白质结构组织及其对 HMGB1 与 DNA 和其他蛋白质相互作用的影响的最新数据。