We achieved a harmonic-rich signal from linear magnetization responses of magnetic nanoparticles under 40 μT/μ ₀ excitation field to facilitate magnetic particle imaging (MPI). In contrast, large harmonic responses are typically attributed to the nonlinear field-dependent magnetization characteristics of the particles, thus questioning technical and clinical issues toward a human-sized MPI scanner. By using a magnetoresistive sensor, we propose a strategy to exploit the linear responses of the tracers at low field regime where the standard MPI may struggle with spatial signal decoding. The achieved high-contrast images of a solid ferucarbotran phantom bring new expectation toward clinical use of MPI.

我们在 40 μ T/ μ ₀激发场下从磁性纳米粒子的线性磁化响应中获得了富含谐波的信号，以促进磁性粒子成像 (MPI)。相比之下，大谐波响应通常归因于粒子的非线性场相关磁化特性，因此质疑人类大小的 MPI 扫描仪的技术和临床问题。通过使用磁阻传感器，我们提出了一种策略来利用示踪剂在低场状态下的线性响应，其中标准 MPI 可能难以进行空间信号解码。所获得的固体ferucarbotran体模的高对比度图像为MPI的临床应用带来了新的期望。