Purpose of Review

To discuss and provide evidence-based data on dietary supplements as part of treating diabetic neuropathy

Recent Findings

Few randomized controlled trials are available, but some have shown beneficial efficacy of various dietary supplements on objective primary endpoints including nerve conduction velocities and axon potentials as well as subjective patient-reported outcomes.

Summary

No medical cure for diabetic neuropathy exists, and prevention is therefore crucial. Tight glucose control slows the progression of nerve damage in diabetes, but an unmet clinical need for effective interventions is warranted. Consequently, a growing number of patients turn to dietary supplements proposed to possess neuroprotective properties. However, the postulated effects are often not evidence-based as they have not been tested scientifically. Taken together, this review will focus on dietary supplements investigated in clinical trials for their potential capabilities in targeting the molecular mechanisms involved in the underlying pathogenesis of diabetic neuropathy.

中文翻译：

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维生素和补充剂治疗糖尿病神经病变的潜在分子方面

审查目的

讨论并提供有关膳食补充剂作为治疗糖尿病性神经病变一部分的循证数据

最近的发现

很少有随机对照试验可用，但有些试验表明各种膳食补充剂对客观主要终点（包括神经传导速度和轴突电位以及主观患者报告的结果）具有有益效果。

概括

糖尿病性神经病变尚无药物治疗方法，因此预防至关重要。严格的血糖控制可以减缓糖尿病中神经损伤的进展，但需要有效干预的临床需求尚未得到满足。因此，越来越多的患者转向建议具有神经保护特性的膳食补充剂。然而，假设的效果通常不是基于证据的，因为它们没有经过科学测试。总之，本综述将重点关注在临床试验中研究的膳食补充剂，以了解它们在靶向糖尿病神经病变潜在发病机制所涉及的分子机制方面的潜在能力。