Metabolic changes occur in all forms of disease but their impact on fibrosis is a relatively recent area of interest. This review provides an overview of the major metabolic pathways, glycolysis, amino acid metabolism and lipid metabolism, and highlights how they influence fibrosis at a cellular and tissue level, drawing on key discoveries in dermal, renal, pulmonary and hepatic fibrosis. The emerging influence of adipose tissue-derived cytokines is discussed and brings a link between fibrosis and systemic metabolism. To close, the concept of targeting metabolism for fibrotic therapy is reviewed, drawing on lessons from the more established field of cancer metabolism, with an emphasis on important considerations for clinical translation.

代谢变化发生在所有形式的疾病中，但它们对纤维化的影响是一个相对较新的兴趣领域。本综述概述了主要代谢途径、糖酵解、氨基酸代谢和脂质代谢，并强调了它们如何在细胞和组织水平上影响纤维化，借鉴了皮肤、肾脏、肺和肝纤维化方面的重要发现。讨论了脂肪组织衍生细胞因子的新影响，并将纤维化和全身代谢联系起来。最后，回顾了纤维化治疗的靶向代谢概念，借鉴了更成熟的癌症代谢领域的经验教训，强调了临床转化的重要考虑因素。