The origin of homochirality is one of the unresolved issues of prebiotic chemistry. Why are the amino acids found in proteins of the l configuration? Perhaps peptido nucleotides could have played a role as transitional species, as suggested visually by the Archaeopteryx in the image. It was recently shown that these phosphoramidate-linked species form spontaneously from simple precursors. Now, the diastereoselectivity of the the dipeptide-forming step has been determined by in-situ NMR spectroscopy, revealing that homochiral products are preferred. This is reported in the Full Paper by C. Richert et al. (DOI: 10.1002/chem.202101630).

中文翻译：

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封面特征：通过 NMR 光谱测定二肽核苷酸形成的非对映选择性（Chem. Eur. J. 54/2021）

同手性的起源是益生元化学尚未解决的问题之一。为什么在l构型的蛋白质中发现了氨基酸？正如图像中始祖鸟在视觉上所暗示的那样，肽核苷酸可能起到了过渡物种的作用。最近表明，这些与氨基磷酸酯相连的物质是由简单的前体自发形成的。现在，二肽形成步骤的非对映选择性已通过原位 NMR 光谱确定，表明优选同手性产物。C. Richert 等人在全文中对此进行了报道。（DOI：10.1002/chem.202101630）。