An N-mesityl thiazolylidene N-heterocyclic carbene (NHC) catalyst delivers significantly improved outcomes in the synthetically-challenging intermolecular aliphatic Stetter reaction, affording 1,4-diketones in high yields and short reaction times without acyloin formation. Stereoelectronic quantification methods optimised for NHCs as organocatalysts gave insights into the observed reactivity, and provide a foundation for ongoing NHC development.

中文翻译：

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用于脂肪族 Stetter 反应的高效 N-Mesityl Thiazolylidene：用于比较 N-杂环卡宾有机催化剂的立体电子定量

一个 Ñ -基thiazolylidene N-杂环卡宾（NHC）催化剂在合成挑战性分子间的脂族stetter反应提供显著改善的结果，得到高收率和短的反应时间的1,4-二酮类，而不偶姻形成。针对作为有机催化剂的 NHC 优化的立体电子量化方法可以深入了解观察到的反应性，并为正在进行的 NHC 开发奠定基础。