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Hydrolytic nondegradable bioactive rosmarinic acid particles
Polymers for Advanced Technologies ( IF 3.4 ) Pub Date : 2021-08-26 , DOI: 10.1002/pat.5481
Mehtap Sahiner 1
Affiliation  

Rosmarinic acid (RS) is as the nonflavonoid polyphenols in the phenolic acid subgroup was cross-linked with sodium trimetaphosphate (STMP) to obtain (p[RS-co-STMP]) particles with the size distribution of 2.992 ± 659 nm. The zeta potential values of p(RS-co-STMP) particles were measured between pH 2–10, and the isoelectric point was determined as pH 2.66. Fe(II) chelating capability test was done for RS and p(RS-co-STMP). At 800 μmol/ml concentrations, p(RS-co-STMP) particles chelated 95.06 ± 5.18% Fe(II), while RS molecule did not chelate Fe(II), whereas STMP chelated only 41.8 ± 5.9% Fe(II). The effects of RS and p(RS-co-STMP) particles on α-glucosidase enzyme activity were investigated and were found to inhibit the α-glucosidase enzyme by 55.7% and 89.6%, respectively. Furthermore, p(RS-co-STMP) particles were modified with polyethyleneimine as m-p(RS-co-STMP) to improve antimicrobial properties and found effective against both Escherichia coli and Staphylococcus aureus bacteria. The interaction of fibrinogen with RS, p(RS-co-STMP) and m-p(RS-co-STMP) were studied via the change in intensity of corresponding fluorescence spectra. It was found that p(RS-co-STMP) particles interacted lesser with fibrinogen than RS and changed the fluorescence property of fibrinogen protein slightly. On the other hand, m-p(RS-co-STMP) particles did not change the fluorescence intensity of fibrinogen suggesting no influence on the blood clotting.

中文翻译:

水解不可降解的生物活性迷迭香酸颗粒

迷迭香酸 (RS) 是将酚酸亚组中的非黄酮类多酚与三偏磷酸钠 (STMP) 交联得到粒径分布为 2.992 ± 659 nm 的 (p[RS-co-STMP]) 颗粒。p(RS-co-STMP) 粒子的 zeta 电位值在 pH 2-10 之间测量,等电点确定为 pH 2.66。对 RS 和 p(RS-co-STMP) 进行了 Fe(II) 螯合能力测试。在 800 μmol/ml 浓度下,p(RS-co-STMP) 颗粒螯合 95.06 ± 5.18% Fe(II),而 RS 分子不螯合 Fe(II),而 STMP 仅螯合 41.8 ± 5.9% Fe(II)。研究了 RS 和 p(RS-co-STMP) 颗粒对 α-葡萄糖苷酶活性的影响,发现分别抑制 55.7% 和 89.6% 的α-葡萄糖苷酶。此外,大肠杆菌金黄色葡萄球菌。通过相应荧光光谱强度的变化研究了纤维蛋白原与 RS、p(RS-co-STMP) 和 mp(RS-co-STMP) 的相互作用。发现p(RS-co-STMP)颗粒与纤维蛋白原的相互作用比RS小,并且略微改变了纤维蛋白原蛋白的荧光特性。另一方面,mp(RS-co-STMP) 颗粒没有改变纤维蛋白原的荧光强度,表明对血液凝固没有影响。
更新日期:2021-11-04
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