Evidence accumulated from past findings indicates that defective proteostasis may contribute to risk factors for cancer generation. Irregular assembly of abnormal proteins catalyzes the disturbance of cellular proteostasis and induces the ability of abnormal cellular proliferation. The autophagy mechanism plays a key role in the regular clearance of abnormal/poor lipids, proteins, and various cellular organelles. The results of functional and effective autophagy deliver normal cellular homeostasis, which establishes supportive metabolism and avoids unexpected tumorigenesis events. Still, the precise molecular mechanism of autophagy in tumor suppression has not been clear. How autophagy triggers selective or nonselective bulk degradation to dissipate tumor promotion under stress conditions is not clear. Under proteotoxic insults to knockdown the drive of tumorigenesis, it is critical for us to figure out the detailed molecular functions of autophagy in human cancers. The current article summarizes autophagy-based theragnostic strategies targeting various phases of tumorigenesis and suggests the preventive roles of autophagy against tumor progression. A better understanding of various molecular partners of autophagic flux will improve and innovate therapeutic approaches based on autophagic-susceptible effects against cellular oncogenic transformation.

中文翻译：

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基于自噬的细胞生理策略靶向致癌进展

从过去的研究结果中积累的证据表明，有缺陷的蛋白质稳态可能导致癌症产生的危险因素。异常蛋白质的不规则组装催化细胞蛋白质稳态的紊乱并诱导异常细胞增殖的能力。自噬机制在异常/不良脂质、蛋白质和各种细胞器的定期清除中起关键作用。功能性和有效自噬的结果可提供正常的细胞稳态，从而建立支持性代谢并避免意外的肿瘤发生事件。尽管如此，自噬在肿瘤抑制中的确切分子机制仍不清楚。自噬如何触发选择性或非选择性的整体降解以在压力条件下消散肿瘤促进尚不清楚。在敲除肿瘤发生驱动的蛋白质毒性损伤下，我们必须弄清楚自噬在人类癌症中的详细分子功能。目前的文章总结了针对肿瘤发生各个阶段的基于自噬的治疗策略，并提出了自噬对肿瘤进展的预防作用。更好地了解自噬通量的各种分子伙伴将改进和创新基于自噬敏感效应对细胞致癌转化的治疗方法。目前的文章总结了针对肿瘤发生各个阶段的基于自噬的治疗策略，并提出了自噬对肿瘤进展的预防作用。更好地了解自噬通量的各种分子伙伴将改进和创新基于自噬敏感效应对细胞致癌转化的治疗方法。目前的文章总结了针对肿瘤发生各个阶段的基于自噬的治疗策略，并提出了自噬对肿瘤进展的预防作用。更好地了解自噬通量的各种分子伙伴将改进和创新基于自噬敏感效应对细胞致癌转化的治疗方法。