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Multiple genome viewer (MGV): a new tool for visualization and comparison of multiple annotated genomes
Mammalian Genome ( IF 2.5 ) Pub Date : 2021-08-27 , DOI: 10.1007/s00335-021-09904-1
Joel E Richardson 1 , Richard M Baldarelli 1 , Carol J Bult 1
Affiliation  

The assembled and annotated genomes for 16 inbred mouse strains (Lilue et al., Nat Genet 50:1574–1583, 2018) and two wild-derived strains (CAROLI/EiJ and PAHARI/EiJ) (Thybert et al., Genome Res 28:448–459, 2018) are valuable resources for mouse genetics and comparative genomics. We developed the multiple genome viewer (MGV; http://www.informatics.jax.org/mgv) to support visualization, exploration, and comparison of genome annotations within and across these genomes. MGV displays chromosomal regions of user-selected genomes as horizontal tracks. Equivalent features across the genome tracks are highlighted using vertical ‘swim lane’ connectors. Navigation across the genomes is synchronized as a researcher uses the scroll and zoom functions. Researchers can generate custom sets of genes and other genome features to be displayed in MGV by entering genome coordinates, function, phenotype, disease, and/or pathway terms. MGV was developed to be genome agnostic and can be used to display homologous features across genomes of different organisms.



中文翻译:

多基因组查看器(MGV):用于可视化和比较多个注释基因组的新工具

16 个近交系小鼠品系(Lilue 等人,Nat Genet 50:1574–1583, 2018)和两个野生衍生品系(CAROLI/EiJ 和 PAHARI/EiJ)(Thybert 等人,Genome Res 28)的组装和注释基因组:448–459, 2018) 是小鼠遗传学和比较基因组学的宝贵资源。我们开发了多基因组查看器(MGV;http://www.informatics.jax.org/mgv)来支持这些基因组内和跨这些基因组的基因组注释的可视化、探索和比较。MGV 将用户选择的基因组的染色体区域显示为水平轨迹。使用垂直“泳道”连接器突出显示基因组轨道上的等效特征。当研究人员使用滚动和缩放功能时,跨基因组的导航是同步的。研究人员可以通过输入基因组坐标、功能、表型、疾病和/或通路术语来生成要在 MGV 中显示的自定义基因组和其他基因组特征。MGV 被开发为与基因组无关,可用于显示不同生物基因组之间的同源特征。

更新日期:2021-08-27
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