Water-soluble pentaamino acid fullerene (C₆₀) derivatives (PFD) are promising nanomaterials with a wide range of biomedical applications. The present study has shown that PFD-7 competitively inhibits aldose reductase and sorbitol dehydrogenase, enzymes of the polyol pathway of glucose metabolism, which are known to be associated with diabetic complications. Treatment with PFD-7 was associated with a decrease in blood glucose level and improvement pancreas and liver morphology in rats with type 2 diabetes mellitus (induced by a high fat diet and streptozotocin). The data obtained indicating the ability of pentaamino acid fullerene (C₆₀) derivatives to exhibit a pronounced antidiabetic effect. Thus, PFD-7 may be considered to contribute significantly to treatment of type 2 diabetes mellitus and diabetic complications.

Graphical abstract

中文翻译：

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水溶性富勒烯衍生物：对多元醇途径酶的抑制作用和对高脂饮食/低剂量链脲佐菌素诱导的大鼠糖尿病的抗糖尿病潜力

水溶性五氨基酸富勒烯 (C ₆₀ ) 衍生物 (PFD) 是具有广泛生物医学应用前景的纳米材料。目前的研究表明，PFD-7 竞争性抑制醛糖还原酶和山梨糖醇脱氢酶，这是葡萄糖代谢多元醇途径的酶，已知它们与糖尿病并发症有关。在患有 2 型糖尿病（由高脂肪饮食和链脲佐菌素诱导）的大鼠中，用 PFD-7 治疗与血糖水平降低和胰腺和肝脏形态改善有关。获得的数据表明五氨基酸富勒烯 (C ₆₀) 衍生物表现出明显的抗糖尿病作用。因此，可以认为PFD-7对2型糖尿病和糖尿病并发症的治疗有显着贡献。

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