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Metabolic flexibility in Trypanosoma cruzi amastigotes: implications for persistence and drug sensitivity
Current Opinion in Microbiology ( IF 5.4 ) Pub Date : 2021-08-26 , DOI: 10.1016/j.mib.2021.07.017
Peter C Dumoulin 1 , Barbara A Burleigh 1
Affiliation  

Throughout their life cycle, parasitic organisms experience a variety of environmental conditions. To ensure persistence and transmission, some protozoan parasites are capable of adjusting their replication or converting to distinct life cycle stages. Trypanosoma cruzi is a ‘generalist’ parasite that is competent to infect various insect (triatomine) vectors and mammalian hosts. Within the mammalian host, T. cruzi replicates intracellularly as amastigotes and can persist for the lifetime of the host. The persistence of the parasites in tissues can lead to the development of Chagas disease. Recent work has identified growth plasticity and metabolic flexibility as aspects of amastigote biology that are important determinants of persistence in varied growth conditions and under drug pressure. A better understanding of the link between amastigote and host/tissue metabolism will aid in the development of new drugs or therapies that can limit disease pathology.



中文翻译:

克氏锥虫无鞭毛体的代谢灵活性:对持久性和药物敏感性的影响

在整个生命周期中,寄生生物会经历各种环境条件。为了确保持久性和传播,一些原生动物寄生虫能够调整它们的复制或转换到不同的生命周期阶段。克氏锥虫是一种“通才”寄生虫,能够感染各种昆虫(triatomine)载体和哺乳动物宿主。在哺乳动物宿主内,T. cruzi作为无鞭毛体在细胞内复制,并且可以在宿主的一生中持续存在。寄生虫在组织中的持续存在可导致恰加斯病的发展。最近的工作已经确定生长可塑性和代谢灵活性是无鞭毛体生物学的一个方面,它们是在不同的生长条件和药物压力下持久性的重要决定因素。更好地了解无鞭毛体和宿主/组织代谢之间的联系将有助于开发可以限制疾病病理学的新药物或疗法。

更新日期:2021-08-27
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