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Interaction between the genetic variant of rs696217-ghrelin and food intake and obesity and dyslipidemia
Annals of Human Genetics ( IF 1.9 ) Pub Date : 2021-08-26 , DOI: 10.1111/ahg.12443
Mehran Yadegari 1 , Reza Zare-Feyzabadi 2 , Mohanna Zakariaeiseraji 3 , Reza Sahebi 4 , Niloofar Shabani 5 , Hamed Khedmatgozar 6 , Gordon A Ferns 7 , Hamideh Ghazizadeh 8, 9 , Maryam Mohammadi-Bajgiran 2, 8 , Melika Jalalian 10 , Mohadese Zoghi 10 , Reza Assaran Darban 10 , Mahdi Mohammadian-Ghosooni 11 , Habibollah Esmaily 12 , Amir Avan 2, 9, 13 , Majid Ghayour-Mobarhan 2, 8
Affiliation  

In this study, we aimed to investigate the relationship between the genetic variant of rs696217-ghrelin and fasted lipid profile, indices of obesity, and environmental parameters. Amplification refractory mutation system-polymerase chain reaction (ARMs-PCR) was used for genotyping 1118 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The interaction between the presence of the genetic variant of rs696217-ghrelin and nutritional intake and other major determinants of obesity and lipid profile was examined in the MASHAD study population. Individuals with the TT genotype at the locus had the lowest prevalence of obesity compared to other genotypes among the individuals. No significant relationship was found between the two groups regarding the lipid profile and TT genotype. Furthermore, no significant association was found between dietary intake and the genetic variant of rs696217-ghrelin in the population under study. Individuals with a TT or GT genotype appear to be at a higher risk of obesity, compared to those with a GG genotype. The results of the current study revealed a significant association between the genetic variant of rs696217-ghrelin and obesity; however, this gene did not correlate with the risk factors of cardiovascular diseases and dyslipidemia in the Iranian population.

中文翻译:

rs696217-ghrelin基因变异与食物摄入、肥胖和血脂异常的相互作用

在这项研究中,我们旨在研究 rs696217-ghrelin 的遗传变异与空腹血脂、肥胖指数和环境参数之间的关系。扩增难治性突变系统-聚合酶链反应 (ARMs-PCR) 用于对作为马什哈德中风和心脏动脉粥样硬化疾病 (MASHAD) 队列研究的一部分招募的 1118 名个体进行基因分型。在 MASHAD 研究人群中检查了 rs696217-ghrelin 遗传变体的存在与营养摄入以及肥胖和血脂谱的其他主要决定因素之间的相互作用。与个体中的其他基因型相比,该基因座具有 TT 基因型的个体的肥胖患病率最低。两组之间在血脂谱和TT基因型方面未发现显着相关性。此外,在所研究的人群中,饮食摄入与 rs696217-ghrelin 的遗传变异之间没有发现显着关联。与具有 GG 基因型的个体相比,具有 TT 或 GT 基因型的个体似乎具有更高的肥胖风险。目前的研究结果揭示了 rs696217-ghrelin 的遗传变异与肥胖之间存在显着关联。然而,该基因与伊朗人群心血管疾病和血脂异常的危险因素无关。目前的研究结果揭示了 rs696217-ghrelin 的遗传变异与肥胖之间存在显着关联。然而,该基因与伊朗人群心血管疾病和血脂异常的危险因素无关。目前的研究结果揭示了 rs696217-ghrelin 的遗传变异与肥胖之间存在显着关联。然而,该基因与伊朗人群心血管疾病和血脂异常的危险因素无关。
更新日期:2021-08-26
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