Diabetes is closely related to the presence of excess HClO induced by endoplasmic reticulum stress. Thus, a novel two-photon fluorescent probe was designed and synthesized for the detection of HClO in the endoplasmic reticulum. Significantly, it has been verified that high glucose can indeed induce oxidative stress of the endoplasmic reticulum and produce excessive HClO. Moreover, the probe has also been successfully used in tissue imaging of diabetic mice.

中文翻译：

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一种新型 ER 靶向双光子荧光探针，用于监测糖尿病小鼠中 HClO 的异常浓度

糖尿病与内质网应激诱导的过量 HClO 的存在密切相关。因此，设计并合成了一种新型双光子荧光探针，用于检测内质网中的 HClO。值得注意的是，已经证实高糖确实可以诱导内质网的氧化应激并产生过量的HClO。此外，该探针还成功用于糖尿病小鼠的组织成像。