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A novel lanthanide-based NIR-II nanoprobe for lung squamous cell carcinoma identification
Biomaterials Science ( IF 6.6 ) Pub Date : 2021-08-12 , DOI: 10.1039/d1bm00766a
Jun Zhu 1 , Lingfei Lu 2 , Yong Fan 2 , Caicun Zhou 1
Affiliation  

The morbidity and mortality of lung cancer, particularly squamous cell carcinoma and non-small-cell lung cancer (NSCLC), is significantly higher than other malignant tumors. Currently, there is a lack of a real-time, nonradioactive detection method for early-stage squamous non-small-cell lung cancer diagnosis. In this study, we introduced fluorescence imaging in the second near-infrared (NIR-II) window to identify in vivo lung squamous cell carcinoma for the first time. A novel nanoprobe is constructed based on downconversion nanoparticles (DCNPs) with a fluorescence core (NaErF4) and an inert shell (NaYF4) coated via the successive layer-by-layer strategy. The existence of the inert shell reduces the surface defects of DCNPs and inhibits the solvent-quenching effect. Therefore, hydrophilic DCNPs exhibit strong NIR-II fluorescence. After modification with an efficient antibody to the squamous cell carcinoma antigen, DCNPs@anti-SCCA nanoprobes exhibited low cytotoxicity and good biocompatibility. These probes can accurately identify lung squamous carcinoma with high tumor-to-normal-tissue ratio as well as high spatial resolution.

中文翻译:

一种用于肺鳞状细胞癌鉴定的新型镧系元素 NIR-II 纳米探针

肺癌,尤其是鳞状细胞癌和非小细胞肺癌(NSCLC)的发病率和死亡率明显高于其他恶性肿瘤。目前,缺乏用于早期鳞状非小细胞肺癌诊断的实时、非放射性检测方法。在这项研究中,我们首次在第二个近红外 (NIR-II) 窗口中引入了荧光成像,以识别体内肺鳞状细胞癌。一种新型纳米探针是基于下转换纳米粒子 (DCNPs) 构建的,具有荧光核 (NaErF 4 ) 和惰性壳 (NaYF 4 ) 涂层通孔逐层策略。惰性壳的存在减少了 DCNPs 的表面缺陷并抑制了溶剂淬灭作用。因此,亲水性 DCNPs 表现出强烈的 NIR-II 荧光。DCNPs@anti-SCCA纳米探针经鳞状细胞癌抗原的高效抗体修饰后,​​表现出低细胞毒性和良好的生物相容性。这些探针可以准确识别具有高肿瘤与正常组织比以及高空间分辨率的肺鳞癌。
更新日期:2021-08-27
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