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Inhibitory effects of luteolin and its derivatives on osteoclast differentiation and differences in luteolin production by Capsicum annuum varieties.
Bioscience, Biotechnology, and Biochemistry ( IF 1.6 ) Pub Date : 2021-10-21 , DOI: 10.1093/bbb/zbab149
Shintaro Onishi 1, 2 , Shinichi Tebayashi 3 , Yasufumi Hikichi 3 , Hiromasa Sawada 4 , Yukiko Ishii 4 , Chul-Sa Kim 3
Affiliation  

Luteolin, an abundant flavonoid in the leaves of Capsicum annuum, has antioxidant activity and is, thus, a key chemical for promoting plant residue utilization, especially for the development of healthcare products. We assessed the inhibitory effect of luteolin and its glycosides on osteoclastic differentiation in human cells and found that the differentiation was effectively inhibited at noncytotoxic concentrations. We also screened 47 varieties of C. annuum for the accumulation of luteolin and apigenin to determine the prevalence of luteolin in diverse cultivars and identify varieties with high and/or selective luteolin production. The glycosides of luteolin and apigenin were found in all the tested varieties, with luteolin predominant over apigenin in most varieties. The identification and characterization of highly productive varieties of C. annuum is expected to be beneficial for the effective development of useful luteolin-based products from plant residues.

中文翻译:

木犀草素及其衍生物对破骨细胞分化的抑制作用以及辣椒品种木犀草素产量的差异。

木犀草素是辣椒叶中丰富的类黄酮,具有抗氧化活性,因此是促进植物残体利用的关键化学物质,特别是用于保健产品的开发。我们评估了木犀草素及其糖苷对人体细胞破骨细胞分化的抑制作用,发现分化在非细胞毒性浓度下得到有效抑制。我们还筛选了 47 个 C. annuum 品种的木犀草素和芹菜素积累,以确定木犀草素在不同品种中的流行情况,并确定具有高和/或选择性木犀草素产量的品种。木犀草素和芹菜素的甙在所有被测品种中均发现,在大多数品种中木犀草素优于芹菜素。C. 高产品种的鉴定和表征
更新日期:2021-08-26
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