PURPOSE To examine self-reported (30-day) sleep versus nightly actigraphy-assessed sleep concordance in long-term survivors of childhood cancer. METHODS Four hundred seventy-seven participants enrolled in the St. Jude Lifetime Cohort (53.5% female, median (range) age 34.3 (19.3-61.6) years, 25.4 (10.9-49.3) years from diagnosis) completed the Pittsburgh Sleep Quality Index and ≥ 3 nights of actigraphy. Participants had neurocognitive impairment and/or a self-reported prolonged sleep onset latency (SOL). Self-reported 30-day sleep and nightly actigraphic sleep measures for sleep duration, SOL, and sleep efficiency (SE) were converted into ordinal categories for calculation of weighted kappa coefficients. General linear models estimated associations between measurement concordance and late effects. RESULTS Agreements between self-reported and actigraphic measures were slight to fair for sleep duration and SOL measures (kw = 0.20 and kw = 0.22, respectively; p < 0.0001) and poor for SE measures (kw = 0.00, p = 0.79). In multivariable models, severe fatigue and poor sleep quality were significantly associated with greater absolute differences between self-reported and actigraphy-assessed sleep durations (B = 26.6 [p < 0.001] and B = 26.8 [p = 0.01], respectively). Survivors with (versus without) memory impairment had a 44-min higher absolute difference in sleep duration (B = 44.4, p < 0.001). Survivors with, versus without, depression and poor sleep quality had higher absolute discrepancies of SOL (B = 24.5 [p = 0.01] and B = 16.4 [p < 0.0001], respectively). Poor sleep quality was associated with a 12% higher absolute difference in SE (B = 12.32, p < 0.0001). CONCLUSIONS Self-reported sleep and actigraphic sleep demonstrated discordance in our sample. Several prevalent late effects were statistically significantly associated with increased measurement discrepancy. Future studies should consider the impacts of late effects on sleep assessment in adult survivors of childhood cancer.

中文翻译：

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儿童癌症成年幸存者自我报告的睡眠与体动记录仪评估的睡眠之间的一致性：心理和神经认知迟发效应的影响。

目的 检查儿童癌症长期幸存者的自我报告（30 天）睡眠与夜间体动记录仪评估的睡眠一致性。方法 参加 St. Jude 终生队列的 477 名参与者（53.5% 为女性，中位年龄（范围）34.3 (19.3-61.6) 岁，诊断后 25.4 (10.9-49.3) 年）完成了匹兹堡睡眠质量指数和≥ 3 晚体动记录仪。参与者有神经认知障碍和/或自我报告的入睡潜伏期（SOL）延长。将自我报告的 30 天睡眠和夜间活动记录睡眠持续时间、SOL 和睡眠效率 (SE) 测量值转换为序数类别，用于计算加权 kappa 系数。一般线性模型估计测量一致性和后期效应之间的关联。结果 对于睡眠持续时间和 SOL 测量，自我报告测量和活动记录测量之间的一致性轻微到一般（分别为 kw = 0.20 和 kw = 0.22；p < 0.0001），而 SE 测量则较差（kw = 0.00，p = 0.79）。在多变量模型中，严重疲劳和睡眠质量差与自我报告和体动记录仪评估的睡眠持续时间之间较大的绝对差异显着相关（分别为 B = 26.6 [p < 0.001] 和 B = 26.8 [p = 0.01]）。有（与无）记忆障碍的幸存者的睡眠时间绝对差异高出 44 分钟（B = 44.4，p < 0.001）。与没有抑郁症和睡眠质量差的幸存者相比，有较高的 SOL 绝对差异（分别为 B = 24.5 [p = 0.01] 和 B = 16.4 [p < 0.0001]）。睡眠质量差与 SE 绝对差异高 12% 相关（B = 12.32，p < 0.0001）。结论 在我们的样本中，自我报告的睡眠和活动记录睡眠表现出不一致。几种普遍存在的迟发效应在统计学上与测量差异的增加显着相关。未来的研究应该考虑晚期影响对儿童癌症成年幸存者睡眠评估的影响。