Aqueous two-phase systems (ATPS) have been demonstrated to be a simple and robust worldwide applied bioprocessing technology. From high value microscopic to macroscopic biological molecules obtained from a wide broad of matrices, ATPS have shown a high efficiency capacity for their concentration, enrichment, recovery, and purification. Particularly in Latin America, four relevant countries have paved the way and played important leading roles in this transformation history. This perspective article aims to present a critical analysis of the practical evolution of the main implementations of ATPS in Argentina, Brazil, Chile, and Mexico. Special attention is given to novel applications of this biphasic bioprocess that are being explored to accomplish visionary therapeutic tasks for the healthcare, biotechnology, and pharmaceutical sectors, as well as other environmental purposes. © 2021 Society of Chemical Industry (SCI).

中文翻译：

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拉丁美洲的水两相系统：前景和未来趋势

水两相系统 (ATPS) 已被证明是一种简单而强大的全球应用生物加工技术。从广泛的基质中获得的高价值微观生物分子到宏观生物分子，ATPS 已显示出其浓缩、富集、回收和纯化的高效能力。特别是在拉丁美洲，四个相关国家在这一转型历史中铺平了道路并发挥了重要的引领作用。这篇观点文章旨在对阿根廷、巴西、智利和墨西哥的 ATPS 主要实施的实际演变进行批判性分析。特别关注这种双相生物过程的新应用，这些应用正在探索中，以完成医疗保健、生物技术和制药行业的有远见的治疗任务，以及其他环保目的。© 2021 化学工业协会 (SCI)。