Microbeam radiotherapy (MRT) is the delivery of spatially fractionated beams that have the potential to offer significant improvements in the therapeutic ratio due to the delivery of micron-sized high dose and dose rate beams. They build on longstanding clinical experience of GRID radiotherapy and more recently lattice-based approaches. Here we briefly overview the preclinical evidence for MRT efficacy and highlight the challenges for bringing this to clinical utility. The biological mechanisms underpinning MRT efficacy are still unclear, but involve vascular, bystander, stem cell and potentially immune responses. There is probably significant overlap in the mechanisms underpinning MRT responses and FLASH radiotherapy that needs to be further defined.

微束放射治疗 (MRT) 是一种空间分割射束的传递，由于传递微米级高剂量和剂量率射束，有可能显着提高治疗率。他们建立在 GRID 放射治疗的长期临床经验和最近基于点阵的方法的基础上。在这里，我们简要概述了 MRT 疗效的临床前证据，并强调了将其应用于临床应用的挑战。支撑 MRT 功效的生物学机制仍不清楚，但涉及血管、旁观者、干细胞和潜在的免疫反应。支持 MRT 反应和 FLASH 放疗的机制可能存在重大重叠，需要进一步确定。