In core–shell nanoparticle analysis, the determination of size distributions of the different particle parts is often complicated, especially in liquid media. Density matching is introduced as a method for analyzing core–shell nanoparticles using Analytical Ultracentrifugation (AUC), making it possible to obtain the core size distribution in liquid dispersions. For this approach, the density of the dispersion is adjusted to the density of the shell. Oil filled nanocapsules are utilized with component densities of around 1 g mL⁻¹ to demonstrate this technique. The shell size distribution is calculated supposing the particle size distribution as a convolution of the shell- and core size distributions. Finally, the distributions of core size, shell thickness, particle size, and particle density and thus particle composition are obtained. To clarify the effect of swelling, AUC measurements are combined with further size characterization methods like Particle Tracking Microscopy and Dynamic Light Scattering.

中文翻译：

---

通过分析超速离心法测定核壳颗粒的粒径、核壳粒径分布

在核壳纳米颗粒分析中，不同颗粒部分的尺寸分布的测定通常很复杂，尤其是在液体介质中。引入密度匹配作为使用分析超速离心 (AUC) 分析核壳纳米粒子的一种方法，从而可以获得液体分散体中的核尺寸分布。对于这种方法，将分散体的密度调整为壳的密度。充油纳米胶囊的使用成分密度约为 1 g mL ^-1来演示这项技术。壳尺寸分布的计算假设颗粒尺寸分布是壳和核尺寸分布的卷积。最后，获得核尺寸、壳厚度、颗粒尺寸和颗粒密度的分布，从而获得颗粒组成。为了阐明膨胀的影响，AUC 测量与进一步的尺寸表征方法相结合，如粒子追踪显微镜和动态光散射。