In this study, the synthesis of TaN nanosheets and their application in theranostic agents is reported. After coating polyethylene glycol (PEG) on the TaN nanosheets, the as-synthesized PEG-modified TaN nanosheets (TaN-PEG) show good stability and biocompatibility. Because of their high absorbance in the near-IR region, TaN-PEG can be utilized as photoacoustic imaging contrast agents for tumor imaging. Moreover, TaN-PEG has significant photothermal conversion performance, exhibiting effective laser-induced tumor ablation capability. The TaN-PEG possessing excellent photoacoustic contrast effect and photothermal properties thus have great promise in theranostic applications, especially imaging-guided cancer treatment.

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用于光声成像引导的光热癌症治疗的氮化钽纳米片

在这项研究中，报道了 TaN 纳米片的合成及其在治疗诊断剂中的应用。在 TaN 纳米片上涂覆聚乙二醇 (PEG) 后，合成的 PEG 修饰的 TaN 纳米片 (TaN-PEG) 显示出良好的稳定性和生物相容性。由于它们在近红外区域的高吸光度，TaN-PEG 可用作肿瘤成像的光声成像造影剂。此外，TaN-PEG 具有显着的光热转换性能，表现出有效的激光诱导肿瘤消融能力。TaN-PEG 具有优异的光声对比效应和光热特性，因此在治疗诊断应用中具有广阔的前景，尤其是成像引导的癌症治疗。