Over the past two decades, circuit-based neurosurgical procedures have gained increasing acceptance as a safe and efficacious approach to the treatment of the intractable obsessive-compulsive disorder (OCD). Lesions and deep brain stimulation (DBS) of the longitudinal corticofugal white matter tracts connecting the prefrontal cortex with the striatum, thalamus, subthalamic nucleus (STN), and brainstem implicate orbitofrontal, medial prefrontal, frontopolar, and ventrolateral cortical networks in the symptoms underlying OCD. The highly parallel distributed nature of these networks may explain the relative lack of adverse effects observed following surgery. Additional pre-post studies of cognitive tasks in more surgical patients are needed to confirm the role of these networks in OCD and to define therapeutic responses to surgical intervention.

在过去的二十年中，基于电路的神经外科手术作为治疗顽固性强迫症 (OCD) 的一种安全有效的方法已获得越来越多的认可。连接前额叶皮层与纹状体、丘脑、底丘脑核 (STN) 和脑干的纵向皮质离性白质束的损伤和深部脑刺激 (DBS) 表明 OCD 潜在症状中的眶额叶、内侧前额叶、额极和腹外侧皮质网络. 这些网络的高度并行分布特性可以解释手术后观察到的副作用相对较少的原因。需要对更多手术患者的认知任务进行额外的事前事后研究，以确认这些网络在强迫症中的作用，并确定对手术干预的治疗反应。