In this study, a blood-compatible polymer, poly(2-methoxyethyl acrylate) (PMEA), was grafted onto a gold substrate with various grafting densities (σ) (σ = 0–0.18 chains nm⁻²), and the amount of hydrated water and mobility of the polymer chain interacting with water molecules were quantitatively evaluated using a quartz crystal microbalance with an admittance system. The amount of hydrated water decreased with increasing σ. By contrast, the mobility of the hydrated PMEA was maximum at σ ≈ 0.12 chains nm⁻², revealing that the amount of high-mobility water at σ = 0.12 was higher than that at other densities. The degree of denaturation of the adsorbed fibrinogen was evaluated based on the hydrodynamic water ratio and viscoelasticity, and was found to increase with increasing σ. The denaturation of adsorbed fibrinogen was suppressed when both the amount of hydrated water and the mobility of hydrated PMEA were high. This study demonstrates that the interfacial state of the polymer chains hydrated in water is important for blood compatibility.

中文翻译：

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水合水量和水合聚（2-甲氧基丙烯酸乙酯）迁移率对吸附纤维蛋白原变性的影响

在这项研究中，一种血液相容性聚合物聚（2-甲氧基丙烯酸乙酯）（PMEA）被接枝到具有不同接枝密度（σ）（σ  = 0–0.18 链 nm ^-2）的金基材上，以及使用带有导纳系统的石英晶体微天平对水合水和聚合物链与水分子相互作用的流动性进行定量评估。水合水量随着σ 的增加而减少。相比之下，水合 PMEA 的迁移率在σ  ≈ 0.12 链 nm ^-2处最大，这表明在σ = 0.12 高于其他密度。吸附的纤维蛋白原的变性程度根据水动力水比和粘弹性评价，发现随着σ的增加而增加。当水合水的量和水合 PMEA 的迁移率都高时，吸附的纤维蛋白原的变性受到抑制。该研究表明，在水中水合的聚合物链的界面状态对血液相容性很重要。