UV-vis and impedance measurements were performed to determine the stable formation of the Hydroxychloroquine-Zinc (HCQ-Zn) complex within the oleic acid (oil) phase of the oil-water system. Decreased UV absorbance with increased Zn concentration was associated with the gradual formation of the complexes within the oil phase, agreeing with existing reports and our time-dependent-density-functional calculations. The reproducibility of our data over a long period indicates the stability of the complex within the oil phase. The impedance measurement showed that the dielectric loss of the oil phase due to the polarization of the complex is less than that due to the polarization of HCQ. A basic impedance measurement revealed that the aqueous-to-oil transfer of Zn is not possible without the HCQ, a result pertinent to the recent report that HCQ is Zn ionophore. Our work is thus important to the fundamental physical chemistry and the current COVID-19 issue where the Zn infusion across the living cell phospholipid membrane (mimicked as an oil-water interface) reduces viral replication.

进行紫外-可见光和阻抗测量以确定在油-水系统的油酸（油）相中羟氯喹-锌（HCQ-Zn）复合物的稳定形成。随着 Zn 浓度的增加，UV 吸光度的降低与油相中络合物的逐渐形成有关，这与现有报告和我们的时间相关密度函数计算一致。我们数据的长期重现性表明油相中复合物的稳定性。阻抗测量表明，由于复合物的极化引起的油相的介电损耗小于由于HCQ极化引起的介电损失。基本阻抗测量表明，没有 HCQ，Zn 的水-油转移是不可能的，与最近关于 HCQ 是 Zn 离子载体的报告相关的结果。因此，我们的工作对基本物理化学和当前的 COVID-19 问题很重要，即通过活细胞磷脂膜（模拟为油-水界面）注入 Zn 减少病毒复制。