Introduction Data on sex-specific lifetime risk of cardiovascular disease (CVD) across the glycemic spectrum, in particular in impaired fasting glucose (IFG) state, are scarce. Whether overweight/obesity modifies the CVD burden also remains unclear. Research design and methods Using a prospective population-based Rotterdam Study, normoglycemia, IFG, and type 2 diabetes mellitus (T2D) were defined. First incident cases of coronary heart disease, heart failure, and stroke during a follow-up time until January 1, 2015 were identified and formed the composite CVD end point. The remaining lifetime risks of CVD were estimated in each glucose category at 55, 65, 75, and 85 years of age, using a modified version of survival analysis adjusted for the competing risk of death. Results Among 5698 women and 3803 men free of CVD at baseline, the mean age was 64.5 years (SD 9.6) and 60.0% of participants were women. At age 55 years, the remaining lifetime risk of any CVD event among women was 55.1% (95% CI 48.3 to 61.9) for IFG, compared with 52.7% (95% CI 49.5 to 55.9) for normoglycemia and 61.5% (95% CI 54.7 to 68.3) for T2D. For men, the remaining lifetime risk of any CVD event was 62.1% (95% CI 55.2 to 69.1) for IFG, compared with 59.1% (95% CI 55.5 to 62.7) for normoglycemia and 60.3% (95% CI 53.1 to 67.5) for T2D. At age 55 years, the lifetime risk for incident CVD was higher, although not statistically significant, among women and men with IFG who were overweight or had obesity compared with normal-weight women and men. Conclusion IFG carried a large lifetime risk for incident CVD among both women and men compared with normoglycemia. In particular among men, the risk was comparable to that of T2D. Overweight/Obesity modifies the risk and conferred a larger burden of lifetime CVD risk among women and men with IFG. Data are available upon reasonable request.

中文翻译：

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女性和男性空腹血糖受损、2 型糖尿病和终生心血管疾病风险：鹿特丹研究

引言 在整个血糖谱中，特别是在空腹血糖受损 (IFG) 状态下，性别特定的心血管疾病 (CVD) 终生风险数据很少。超重/肥胖是否会改变 CVD 负担也尚不清楚。研究设计和方法 使用一项基于人群的前瞻性鹿特丹研究，定义了正常血糖、IFG 和 2 型糖尿病 (T2D)。确定了截至 2015 年 1 月 1 日的随访期间的首例冠心病、心力衰竭和中风病例，并形成了复合 CVD 终点。在 55、65、75 和 85 岁的每个葡萄糖类别中，使用针对竞争性死亡风险调整的生存分析的修改版本估计了 CVD 的剩余终生风险。结果 在基线时没有 CVD 的 5698 名女性和 3803 名男性中，平均年龄为 64 岁。5 年 (SD 9.6) 和 60.0% 的参与者是女性。在 55 岁时，IFG 女性发生任何 CVD 事件的剩余终生风险为 55.1%（95% CI 48.3 至 61.9），而正常血糖为 52.7%（95% CI 49.5 至 55.9）和 61.5%（95% CI） 54.7 到 68.3) 用于 T2D。对于男性，IFG 的任何 CVD 事件的剩余终生风险为 62.1%（95% CI 55.2 至 69.1），而正常血糖为 59.1%（95% CI 55.5 至 62.7）和 60.3%（95% CI 53.1 至 67.5）对于 T2D。在 55 岁时，与体重正常的女性和男性相比，在超重或肥胖的 IFG 女性和男性中，发生 CVD 的终生风险更高，尽管没有统计学意义。结论 与正常血糖相比，IFG 在女性和男性中都有很大的终生 CVD 风险。特别是在男性中，风险与 T2D 相当。超重/肥胖改变了风险，并赋予了 IFG 女性和男性更大的终生 CVD 风险负担。可应合理要求提供数据。