Structural and functional abnormalities in the cerebellar region have been shown in patients with Parkinson’s disease (PD). Since the cerebellar region has been associated with cognitive and lower-limb motor functions, it is imperative to study cerebellar oscillations in PD. Here, we evaluated cerebellar electroencephalography (EEG) during cognitive processing and lower-limb motor performances in PD. Cortical and cerebellar EEG were collected from 74 PD patients and 37 healthy control subjects during a 7-second interval timing task, 26 PD patients and 13 controls during a lower-limb pedaling task, and 23 PD patients during eyes-open/closed resting conditions. Analyses were focused on the mid-cerebellar Cbz electrode and further compared to the mid-occipital Oz and mid-frontal Cz electrodes. Increased alpha-band power was observed during the eyes-closed resting-state condition over Oz, but no change in alpha power was observed over Cbz. PD patients showed higher dispersion when performing the 7-second interval timing cognitive task and executed the pedaling motor task with reduced speed compared to controls. PD patients exhibited attenuated cue-triggered theta-band power over Cbz during both the interval timing and pedaling motor tasks. Connectivity measures between Cbz and Cz showed theta-band differences, but only during the pedaling motor task. Cbz oscillatory activity also differed from Oz across multiple frequency bands in both groups during both tasks. Our cerebellar EEG data along with previous magnetoencephalography and animal model studies clearly show the alteration in the cerebellar oscillations during cognitive and motor processing in PD.

帕金森病 (PD) 患者已发现小脑区域的结构和功能异常。由于小脑区域与认知和下肢运动功能相关，因此研究 PD 中的小脑振荡势在必行。在这里，我们评估了 PD 患者认知处理和下肢运动表现期间的小脑脑电图 (EEG)。在 7 秒间隔计时任务期间从 74 名 PD 患者和 37 名健康对照受试者、在下肢蹬踏任务期间收集 26 名 PD 患者和 13 名对照者以及在睁眼/闭眼休息条件下从 23 名 PD 患者收集皮质和小脑脑电图. 分析集中在小脑中部 Cbz 电极，并进一步与枕中 Oz 和中额 Cz 电极进行比较。在 Oz 上的闭眼静止状态条件下观察到增加的 alpha 波段功率，但在 Cbz 上没有观察到 alpha 功率的变化。与对照组相比，PD 患者在执行 7 秒间隔计时认知任务时表现出更高的分散性，并且以较低的速度执行踏板运动任务。PD 患者在间隔时间和蹬踏运动任务期间表现出减弱的 Cbz 上的线索触发 theta 波段功率。Cbz 和 Cz 之间的连通性测量显示了 theta 频带差异，但仅在踏板运动任务期间。在两项任务期间，两组中的多个频带的 Cbz 振荡活动也与 Oz 不同。