Background

Alterations of brain signal complexity may reflect brain functional abnormalities. In adolescent bipolar disorder (ABD) distribution of brain regions showing abnormal complexity in different mood states remains unclear. We aimed to analyze brain entropy (BEN) alteration of functional magnetic resonance imaging (fMRI) signal to observe spatial distribution of complexity in ABD patients, as well as the relationship between this variation and clinical variables.

Methods

Resting-state fMRI data were acquired from adolescents with bipolar disorder (BD) who were in manic (n = 19) and euthymic (n = 20) states, and from healthy controls (HCs, n = 17). The differences in BEN among the three groups, and their associations with clinical variables, were examined.

Results

Compared to HCs, manic and euthymic ABD patients showed increased BEN in right parahippocampal gyrus (PHG) and left dorsolateral prefrontal cortex (DLPFC). There was no significant difference of BEN between the manic and the euthymic ABD groups. In manic ABD patients, right PHG BEN exhibited significantly positive relationship with episode times.

Conclusions

Increased BEN in right PHG and left DLPFC in ABD patients may cause dysfunction of corticolimbic circuitry which is important to emotional processing and cognitive control. The positive correlation between PHG BEN and episode times of manic ABD patients further expressed a close association between brain complexity and clinical symptoms. From the perspective of brain temporal dynamics, the present study complements previous findings that have reported corticolimbic dysfunction as an important contributor to the pathophysiology of BD. BEN may provide valuable evidences for understanding the underlying mechanism of ABD.

中文翻译：

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躁狂和心境正常的青少年双相情感障碍患者海马旁回和背外侧前额叶皮层静息态脑熵增加

背景

大脑信号复杂性的改变可能反映了大脑功能异常。在青少年双相情感障碍 (ABD) 中，在不同情绪状态下表现出异常复杂性的大脑区域的分布仍不清楚。我们旨在分析功能磁共振成像 (fMRI) 信号的脑熵 (BEN) 改变，以观察 ABD 患者复杂性的空间分布，以及这种变异与临床变量之间的关系。

方法

静息状态 fMRI 数据来自躁郁症 (BD) 处于躁狂 (n = 19) 和心境正常 (n = 20) 状态的青少年，以及健康对照 (HC，n = 17)。检查了三组之间 BEN 的差异及其与临床变量的关联。

结果

与 HC 相比，躁狂和心境正常的 ABD 患者在右侧海马旁回 (PHG) 和左侧背外侧前额叶皮层 (DLPFC) 中显示出增加的 BEN。躁狂和心境正常的 ABD 组之间的 BEN 没有显着差异。在躁狂 ABD 患者中，右侧 PHG BEN 与发作时间呈显着正相关。

结论

ABD 患者右侧 PHG 和左侧 DLPFC 的 BEN 增加可能导致皮质边缘回路功能障碍，这对情绪处理和认知控制很重要。PHG BEN 与躁狂 ABD 患者发作时间的正相关进一步表达了大脑复杂性与临床症状之间的密切关联。从脑时间动力学的角度来看，本研究补充了先前报告皮质边缘功能障碍是 BD 病理生理学的重要因素的研究结果。BEN 可能为理解 ABD 的潜在机制提供有价值的证据。