To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694_295–303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.

调查是否产生针对鸟分枝杆菌亚种的抗体。副结核病( MAP ) 与多发性硬化症 (MS) 的临床特征和人类白细胞抗原( HLA ) 等位基因有关，在 103 名 MS 患者和 50 名健康对照者的血清中测量了针对三种MAP肽和两种与MAP同源的人类肽的IgG 抗体。碳氢化合物）。MS患者具有针对MAP2694更高的IgG水平_295-303比的HC（MAP2694-IgG）的，而其他抗体是相当的。多变量分析表明，较高的 MAP2694-IgG 滴度与较高的 EDSS 评分相关，但与HLA无关等位基因或乳制品消费。针对MAP 的免疫反应可能会加重 MS 残疾。