A multimeric MRI blood pool contrast agent based on the closo-borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized closo-borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement in vitro and in vivo.

中文翻译：

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两亲性 DTPA 多聚体组装在二十面体闭硼烷基体上作为高性能 MRI 血池造影剂

报道了一种基于近硼烷基序的多聚体 MRI 血池造影剂。使用氨基甲酸酯键将十二个具有胺端基的两亲性 DTPA 螯合物附加在碳酸酯官能化的氯代硼烷基序上。修饰的 DTPA 螯合物上存在的外周苯基导致高人血清白蛋白结合、高弛豫性和出色的体外和体内对比度增强。