Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures. In this review, we discuss clathrin structure and coated vesicle formation, how clathrin is utilised within different cellular processes including synaptic vesicle recycling, hormone desensitisation, spermiogenesis, cell migration and mitosis, and how clathrin's remarkable ‘shapeshifting’ ability to form diverse lattice structures might contribute to its multiple cellular functions.

中文翻译：

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网格蛋白：分子变形剂

网格蛋白以其对网格蛋白介导的内吞作用的贡献而闻名，但它也参与多种细胞功能。关键是网格蛋白能够组装成多面体晶格，包括弯曲的足球或篮子形状、扁平晶格甚至管状结构。在这篇综述中，我们讨论了网格蛋白的结构和包被囊泡的形成，网格蛋白如何在不同的细胞过程中被利用，包括突触囊泡回收、激素脱敏、精子发生、细胞迁移和有丝分裂，以及网格蛋白显着的“变形”能力如何形成不同的晶格结构有助于其多种细胞功能。