The association between baseline perfusion measures and clinical outcomes in patients with acute small subcortical infarcts (SSIs) has not been studied in detail. Post-processed acute perfusion CT and follow-up diffusion-weighted imaging of 71 patients with SSIs were accurately co-registered. Relative perfusion values were calculated from the perfusion values of the infarct lesion divided by those of the mirrored contralateral area. The association between perfusion measures with clinical outcomes and the interaction with intravenous thrombolysis were studied. Additionally, the perfusion measures for patients having perfusion CT before and after thrombolysis were compared. Higher contralateral hemispheric cerebral blood flow (CBF) was the only independent predictor of an excellent clinical outcome (modified Rankin Scale of 0-1) at 3 months (OR = 1.3, 95% CI 1.1–1.4, P = 0.001) amongst all the perfusion parameters, and had a significant interaction with thrombolysis (P = 0.04). Patients who had perfusion CT after thrombolysis demonstrated a better perfusion profile (relative CBF ≥1) than those who had perfusion CT before thrombolysis (After:45.5%, Before:21.1%, P = 0.03). This study implies that for patients with SSIs, hemispheric CBF is a predictor of clinical outcome and has an influence on the effect of intravenous thrombolysis.

尚未详细研究急性小皮质下梗死 (SSI) 患者的基线灌注测量值与临床结果之间的关联。对 71 例 SSI 患者的后处理急性灌注 CT 和随访弥散加权成像进行了准确的联合配准。相对灌注值由梗塞病变的灌注值除以镜像对侧区域的灌注值计算。研究了灌注测量与临床结果之间的关联以及与静脉溶栓的相互作用。此外，比较了溶栓前后灌注CT患者的灌注措施。较高的对侧半球脑血流量 (CBF) 是 3 个月时（OR = 1. 3, 95% CI 1.1–1.4, P = 0.001）在所有灌注参数中，并且与溶栓有显着的相互作用（P = 0.04）。溶栓后灌注 CT 的患者比溶栓前灌注 CT 的患者表现出更好的灌注曲线（相对 CBF ≥1）（之后：45.5%，之前：21.1%，P = 0.03）。这项研究表明，对于 SSI 患者，半球 CBF 是临床结果的预测因子，并且对静脉溶栓的效果有影​​响。