Purpose: 

To analyze the nature of multiple evanescent white dot syndrome (MEWDS) and differentiate an idiopathic or primary form of MEWDS from a secondary form that is seen in association with other clinical conditions affecting the posterior segment of the eye.

Methods: 

Clinical and multimodal imaging findings including color fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography of patients with secondary MEWDS are presented.

Results: 

Twenty consecutive patients with secondary MEWDS were evaluated. Fifteen patients were female. Most were young adults aged between 20 to 40 years with myopia (less than −6 diopters). Pathologic conditions associated with the secondary MEWDS reaction were high myopia (greater than −6 diopters) in two eyes, previous vitreoretinal surgery for rhegmatogenous retinal detachment in 2 eyes, and manifestations of multifocal choroiditis in 18 eyes. In all eyes, the MEWDS lesions followed a course of progression and resolution independent from the underlying condition.

Conclusion: 

Secondary MEWDS seems to be an epiphenomenon (“EpiMEWDS”) that may be seen in association with clinical manifestations disruptive to the choriocapillaris–Bruch membrane–retinal pigment epithelium complex.

中文翻译：

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多发性消失白点综合症有两种形式吗？

目的： 

分析多发性消失白点综合征 (MEWDS) 的性质，并将 MEWDS 的特发性或原发性形式与与影响眼后段的其他临床病症相关的继发性形式区分开来。

方法： 

介绍了继发性 MEWDS患者的临床和多模态成像结果，包括彩色眼底摄影、眼底自发荧光、荧光素血管造影、吲哚菁绿血管造影、谱域光学相干断层扫描和光学相干断层扫描血管造影。

结果： 

对 20 名连续患有继发性 MEWDS 的患者进行了评估。十五名患者为女性。大多数是年龄在 20 至 40 岁之间的近视（屈光度低于 -6）的年轻人。与继发性 MEWDS反应相关的病理状况为 2 只眼高度近视（大于 -6 屈光度），2 只眼曾接受过孔源性视网膜脱离玻璃体视网膜手术，18 只眼有多灶性脉络膜炎表现。在所有眼睛中，MEWDS 病变都遵循一个独立于潜在病症的进展和消退过程。

结论： 

继发性 MEWDS似乎是一种附带现象（“EpiMEWDS”），可能与破坏脉络膜毛细血管 - 布鲁赫膜 - 视网膜色素上皮复合体的临床表现有关。