Abstract

Background

Study examines the influence of cardiac rehabilitation program (CR) on left ventricular diastolic dysfunction (LVDD), functional capacity and major cardiovascular risk factors (CVRF) in patients after with PCI resolved acute coronary syndrome (ACS).

Methods

We performed a non-randomised study included a total of 85 subjects after resolved ACS, with left ventricular ejection fraction (LVEF) ≥ 45% and LVDD, without heart failure. Subjects were divided into control (N = 29) and intervention group (N = 56), depending on CR program attendance consisted of exercise training sessions for 12 weeks, 3 times per/week, 30 min per session. Initially and after 12 weeks, patients were subjected to echocardiography to assess LV filling pressure (E/e’) as well as CPET to asses improvement in peak VO_2.

Results

Initially subjects were similar in CVRF, LVDD and CPET parameters (p > 0.05). Following CR, the intervention group demonstrated a significant improvement in E/e’ (8.0 ± 3.0 vs 7.0 ± 2.2; p < 0.05), compared to the control group (8.4 ± 3.0 vs 9.0 ± 3.1; p > 0.05), as well as a significant improvement in peak VO₂ (23.2 ± 5.0 ml/kg/min vs 24.8 ± 5.8 ml/kg/min; p < 0.001). Control group also exhibited significant worsening in peak VO₂ without CR (23.0 ± 4.0 vs 21.2 ± 4.1 ml/kg/min; p = 0.02). CVRF improved in both groups, except for glycaemia levels and body mass index, which improved only in the intervention group (p < 0.001).

Conclusions

Following ACS treated with PCI, CR had a positive effect on major CVRFs, the degree of LVDD and exercise capacity and should be considered as effective tool to reduce morbidity in such patients.

中文翻译：

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心脏康复对急性冠脉事件后经皮冠状动脉介入治疗患者左心室舒张功能和运动能力的影响

摘要

背景

研究检查了心脏康复计划 (CR) 对 PCI 解决急性冠脉综合征 (ACS) 后患者左心室舒张功能障碍 (LVDD)、功能能力和主要心血管危险因素 (CVRF) 的影响。

方法

我们进行了一项非随机研究，共纳入 85 名 ACS 缓解后左心室射血分数 (LVEF) ≥ 45% 和 LVDD，无心力衰竭的受试者。受试者分为对照组（N  = 29）和干预组（N  = 56），这取决于 CR 计划的出席情况，包括为期 12 周的运动训练课程，每周 3 次，每次 30 分钟。最初和 12 周后，患者接受超声心动图评估 LV 充盈压 (E/e') 以及 CPET 评估峰值 VO _{2 的改善。}

结果

最初受试者的 CVRF、LVDD 和 CPET 参数相似 ( p  > 0.05)。 CR 后，与对照组（8.4 ± 3.0 对比 9.0 ± 3.1；p  > 0.05）相比，干预组在 E/e' 方面也有显着改善（8.0 ± 3.0 对比 7.0 ± 2.2；p < 0.05）作为峰值 VO ₂的显着改善（23.2 ± 5.0 ml/kg/min 对比 24.8 ± 5.8 ml/kg/min；p  < 0.001）。_{对照组在没有 CR 的情况下也表现出峰值 VO 2}的显着恶化（23.0 ± 4.0 对比 21.2 ± 4.1 ml/kg/min；p  = 0.02）。除了血糖水平和体重指数仅在干预组有所改善外，两组的 CVRF 均有所改善 ( p  < 0.001)。

结论

在接受 PCI 治疗的 ACS 后，CR 对主要 CVRF、LVDD 程度和运动能力有积极影响，应被视为降低此类患者发病率的有效工具。