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Metal-organic frameworks for diagnosis and therapy of infectious diseases
Critical Reviews in Microbiology ( IF 6.5 ) Pub Date : 2021-08-25 , DOI: 10.1080/1040841x.2021.1950120
Christian Rafael Quijia 1 , Renata Carolina Alves 1 , Gilmar Hanck-Silva 1 , Regina Célia Galvão Frem 2 , Guilherme Arroyos 2 , Marlus Chorilli 1
Affiliation  

Abstract

Infectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review provides a detailed summary of the biological application of MOFs, focussing on diagnosis and treatment of infectious diseases. MOFs have been reported for usage as antimicrobial agents, drug delivery systems, therapeutic composites, nanozymes and phototherapies. Furthermore, different MOF-based biosensors have also been developed to detect specific pathogens by electrochemical, fluorometric and colorimetric assays. Finally, we present limitations and perspectives in this field.



中文翻译:

用于传染病诊断和治疗的金属有机框架

摘要

传染病是全球死亡率和发病率的主要原因之一。金属有机框架 (MOF) 是由桥接有机配体和金属离子或簇组成的多孔配位材料,在对抗细菌、病毒、真菌和原生动物等多种病原体方面表现出巨大的潜力。MOFs 具有缓释能力、高表面积、可调节孔径和结构灵活性,这使其成为新治疗系统的良好候选者。本综述详细总结了 MOF 的生物学应用,重点关注传染病的诊断和治疗。据报道,MOF 可用作抗菌剂、药物递送系统、治疗复合材料、纳米酶和光疗法。此外,还开发了不同的基于 MOF 的生物传感器,以通过电化学、荧光和比色测定来检测特定的病原体。最后,我们提出了该领域的局限性和观点。

更新日期:2021-08-25
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