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Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics
Trends in Analytical Chemistry ( IF 13.1 ) Pub Date : 2021-08-26 , DOI: 10.1016/j.trac.2021.116424
Tugba Ozer 1 , Charles S Henry 2, 3
Affiliation  

The importance of user-friendly, inexpensive, sensitive, and selective detection of viruses has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) pandemic. Among the analytical tools, paper-based devices (PADs) have become a leading alternative for point-of-care (POC) testing. In this review, we discuss the recent development strategies and applications in nucleic acid-based, antibody/antigen-based and other affinity-based PADs using optical and electrochemical detection methods for sensing viruses. In addition, advantages and drawbacks of presented PADs are identified. Current state and insights towards future perspectives are presented regarding developing POC diagnosis platform for COVID-19. This review considers state-of-the-art technologies for further development and improvement in PADs performance for virus detection.



中文翻译:

用于病毒检测的纸质分析设备:当前和未来流行病的最新策略

由于最近的 2019 年冠状病毒病 (COVID-19) 大流行,用户友好、廉价、灵敏和选择性病毒检测的重要性再次得到强调。在分析工具中,纸质设备 (PAD) 已成为现场护理 (POC) 测试的主要替代品。在这篇综述中,我们讨论了使用光学和电化学检测方法来传感病毒的基于核酸、基于抗体/抗原和其他基于亲和力的 PAD 的最新开发策略和应用。此外,还确定了所提出的 PAD 的优点和缺点。介绍了有关开发 COVID-19 POC 诊断平台的现状和对未来前景的见解。本次审查考虑了进一步开发和改进 PAD 病毒检测性能的最先进技术。

更新日期:2021-09-03
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