Additional occurrence data are needed to better understand human exposure to per- and poly-fluoroalkyl substances (PFAS) from commercially available foods in the United States. The Food and Drug Administration’s (FDA) Total Diet Study (TDS) collects foods that are both nationally and regionally distributed. In 2018, 172 processed foods were collected from grocery stores around Lenexa, KS, as part of the TDS national collection. A previously developed method for the analysis of PFAS in foods as part of the TDS regional collection was modified and optimized for these samples. This method was single lab validated using 5 different matrices and method detection limits were calculated. During the analysis of these samples, challenges arose with method blanks and further investigation into statistical methods to distinguish between blank and sample concentrations were done. The confirmation of two short chain PFAS, perfluorobutanoic acid (PFBA) and perfluoropentanoic acid (PFPeA), was not possible using triple quadrupole mass spectrometry and a confirmation method was developed using high-resolution mass spectrometry. This technique was also used to investigate potential detections and interferents that fell within the retention time criteria for positive detections. In the national collection, positive detections of perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA) were found in frozen fish sticks/patties, PFOS and perfluorodecanoic acid (PFDA) in canned tuna, and PFOS in protein powder. Concentrations were all below 150 ppt, and no other detects were confirmed above the method detection limits in any other foods.

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来自 FDA 总膳食研究的加工食品中全氟和多氟烷基物质 (PFAS) 的分析

需要更多的发生数据来更好地了解人类对美国市售食品中全氟和多氟烷基物质 (PFAS) 的暴露情况。美国食品和药物管理局 (FDA) 的总膳食研究 (TDS) 收集了全国和地区分布的食品。2018 年，作为 TDS 国家收集的一部分，从堪萨斯州 Lenexa 附近的杂货店收集了 172 种加工食品。作为 TDS 区域收集的一部分，先前开发的用于分析食品中 PFAS 的方法已针对这些样品进行了修改和优化。该方法使用 5 种不同的基质进行了单一实验室验证，并计算了方法检测限。在分析这些样品的过程中，方法空白带来了挑战，并进一步研究了统计方法以区分空白和样品浓度。使用三重四极杆质谱法无法确认两种短链 PFAS，即全氟丁酸 (PFBA) 和全氟戊酸 (PFP​​eA)，因此开发了一种使用高分辨率质谱法的确认方法。该技术还用于调查潜在检测和符合阳性检测保留时间标准的干扰物。在国家收集中，冷冻鱼条/肉饼中的全氟辛烷磺酸（PFOS）和全氟壬酸（PFNA）、金枪鱼罐头中的全氟辛烷磺酸和全氟癸酸（PFDA）以及蛋白粉中的全氟辛烷磺酸（PFOS）检测出阳性。浓度均低于 150 ppt，

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