Objective

To develop a model for quantitative comparison of elutable substances by direct elution from resin-bonded composite (RBC) test specimens versus indirect elutability of substances from RBC-restored teeth. Furthermore, it was to be investigated whether the different composites of the Tetric® RBC product family release different types and amounts of substances.

Methods

Four different composite materials from the Tetric® product family were studied. For each material subgroup ten human third molar teeth were prepared with standard Class-I occlusal cavities. These ‘tooth group’ specimens were provided with a three-step adhesive system (incorporating TEGDMA) and the respective composite restoration. Same sized control specimens, of each RBC restorative material, were prepared (‘direct RBC’ groups). All specimens were placed in individual elution chambers such that the elution media (ethanol/water, 3:1) only came into contact with either the tooth root or ¾ height of the ‘direct RBC’ materials. They were incubated at 37 °C for up to 7 d. Samples of the eluant were taken after 1, 2, 4 and 7 d and were analysed by high-temperature gas chromatography/mass spectrometry.

Results

Bisphenol A ethoxylate dimethacrylate (bisEMA), bisphenol A glycidyldimethacrylate (bisGMA), tetraethylene glycol dimethacrylate (TEEGDMA), decan-1,10-diol dimethacrylate (DDDMA) were mostly found in the eluates of the ‘direct RBC’ groups in statistically significantly greater amounts than in the eluates of the ‘tooth groups’. Such quantitative differences were also the case with eluates containing bisphenol A (BPA), dicyclohexyl phthalate (DCHP) and drometrizole, which are common in the environment. In contrast to the behavior found with all the other monomers, up to 3 orders of magnitude more triethylene glycol dimethacrylate (TEGDMA) was found in the ‘tooth groups’ compared to the ‘direct RBC’ groups, evidently released by the adhesive system.

Significance

The release of most of the substances was clearly delayed in the ‘tooth groups’ indicative of their chronic, rather than acute, elution to the oral environment. A barrier function of the residual dentin layer and the adhesion layer can be inferred. The different release patterns of substances from the various composites of the RBC product family is a manifestation of their different and indication-specific compositions. Consideration of an overall restorative care (RBC plus adhesive) system, when assessing the total amount of released substances, is emphasized.

中文翻译：

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从 RBC 产品系列中直接和间接洗脱单体

客观的

开发一个模型，用于定量比较树脂结合复合材料 (RBC) 试样直接洗脱的可洗脱物质与 RBC 修复牙齿的物质间接洗脱性。此外，还需要调查 Tetric® RBC 产品系列的不同复合材料是否会释放不同类型和数量的物质。

方法

研究了来自 Tetric® 产品系列的四种不同复合材料。对于每个材料亚组，用标准 I 类咬合腔制备十颗人类第三磨牙。这些“牙齿组”标本配有三步粘合系统（包含 TEGDMA）和相应的复合修复体。制备每种 RBC 修复材料的相同大小的对照样本（“直接 RBC”组）。所有样品置于单独的腔室洗脱使得洗脱介质（乙醇/水，3：1）仅开始接触任一齿根或“直接 RBC”材料的 ¾ 高度。它们在 37°C 下培养长达 7 天。在 1、2、4 和 7 天后采集洗脱液样品，并通过高温气相色谱/质谱进行分析。

结果

双酚 A 乙氧基化物二甲基丙烯酸酯 (bisEMA)、双酚 A 缩水甘油二甲基丙烯酸酯 (bisGMA)、四乙二醇二甲基丙烯酸酯 (TEEGDMA)、癸二酸 1,10-二醇二甲基丙烯酸酯 (DDDMA) 主要存在于“直接 RBC”组的洗脱液中，在统计学上显着高于比“牙齿组”的洗脱液中的数量多。这种数量差异也存在于含有双酚 A (BPA)、邻苯二甲酸二环己酯 (DCHP) 和屈美三唑的洗脱液中，它们在环境中很常见。与在所有其他单体中发现的行为相比，在“牙齿组”中发现的三甘醇二甲基丙烯酸酯 (TEGDMA) 比“直接 RBC”组高 3 个数量级，这显然是由粘合剂系统释放的。

意义

大多数物质的释放在“牙齿组”中明显延迟，表明它们是慢性而不是急性洗脱到口腔环境中的。可以推断残留牙本质层和粘附层的屏障功能。来自 RBC 产品系列的各种复合材料的物质的不同释放模式是它们不同且针对特定适应症的成分的体现。在评估释放物质的总量时，强调考虑整体修复护理（RBC 加粘合剂）系统。