Purpose

To evaluate the association of systemic immune-inflammation index (SII) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) with severity of noninfectious uveitis.

Methods

This retrospective study included 46 patients with noninfectious uveitis (uveitis group) and 46 age- and sex-matched healthy subjects (control group). The demographic and ocular findings, localization, and activity of uveitis were recorded at the time of onset evaluation. SII, NLR, and PLR levels of patients were compared between the groups.

Results

SII, NLR, and PLR levels were significantly higher in uveitis group when compared to control group (p < 0.001, p = 0.005, and p = 0.001, respectively). While SII and NLR were significantly higher in severe anterior uveitis than mild anterior uveitis (p = 0.006 and p = 0.021, respectively), only SII was significantly higher in severe posterior and panuveitis than mild ones (p = 0.038).

Conclusion

SII, as a novel inflammation index, may be more significant tool than NLR and PLR in determining the severity of the uveitis. Furthermore, SII may be a potential useful index in clinical practice to follow-up and manage these patients by monitoring response to anti-inflammatory treatment modalities.

中文翻译：

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评估全身免疫炎症指数水平作为非感染性葡萄膜炎严重程度的新标志

目的

评估全身免疫炎症指数 (SII) 水平、中性粒细胞/淋巴细胞比率 (NLR) 和血小板/淋巴细胞比率 (PLR) 与非感染性葡萄膜炎严重程度的关联。

方法

这项回顾性研究包括 46 名非感染性葡萄膜炎患者（葡萄膜炎组）和 46 名年龄和性别匹配的健康受试者（对照组）。在开始评估时记录人口统计学和眼部发现、定位和葡萄膜炎的活动。比较各组患者的SII、NLR和PLR水平。

结果

与对照组相比，葡萄膜炎组的 SII、NLR 和 PLR 水平显着更高（分别为p  < 0.001、p  = 0.005 和p  = 0.001）。虽然严重前葡萄膜炎的 SII 和 NLR 显着高于轻度前葡萄膜炎（分别为p  = 0.006 和p  = 0.021），但只有严重后葡萄膜炎和全葡萄膜炎的 SII 显着高于轻度前葡萄膜炎（p  = 0.038）。

结论

SII 作为一种新的炎症指标，在确定葡萄膜炎的严重程度方面可能是比 NLR 和 PLR 更重要的工具。此外，SII 可能是临床实践中通过监测对抗炎治疗方式的反应来跟踪和管理这些患者的潜在有用指标。